Lab Director

Santiago Ortega-Gutierez

Santiago Ortega-Gutiérrez, MD, MSc, FAHA, FSVIN

Dr Santiago Ortega earned his MD at University of Alcala in Madrid Spain, did his Internal Medicine and Neurology residency at the Medical College of Wisconsin, completed a Neurocritical care and Stroke Fellowship at Columbia University, and an Endovascular Neurosurgery fellowship at Mount Sinai in New York. He is currently the Director of Neuro Interventional Surgery in Neurology at UI and the Neuroendovascular Surgical Neuroradiology Fellowship Director. He is also the Vice Chair of the Mechanical Thrombectomy 2020+ initiative and President of the Society of Vascular and Interventional Neurology. His research interest includes cerebral autoregulation and hemodynamics, neuroimaging as a selection tool and developing novel endovascular approaches and devices to treat cerebrovascular ischemic and hemorrhagic disease. Currently Dr. Ortega-Gutierrez has over 300 publications in peer-reviewed journals as well as he is the PI in several NIH/NINDS, PCORI and industry funded investigator-initiated studies and Randomized Trials including MAP-STROKE, DIRECT and DONE SYMPLE.

Lab Managers

Carlos2026C

Carlos A Contreras-Mesa, MS

Title/Position
Clinical Trial & Lab Manager
Carlos Contreras Mesa is a cross-sector project manager whose work spans multinational clinical research, public-sector innovation, and AI-driven technology. As Project Manager and Lab Manager of the Cerebrovascular & Neurointerventional Laboratory at University of Iowa Health Care, he directs two concurrent multinational clinical trials across a 40-site network and oversees a combined $15M research portfolio under strict ICH-GCP and FDA compliance. He also led the development of "Jarín-Jarín," an AI system that analyzes satellite and drone imagery to monitor public-works progress and flag stalled projects; a venture that reached the top-5 finalists among 36 startups from 17 countries. He holds a Master of Science in Project Management from UDIMA and is a recognized AI educator who teaches advanced techniques such as Chain of Thought for critical thinking and dynamic content generation.
Milagros Galecio-Castillo

Milagros Galecio-Castillo

Title/Position
Lead Scientist
Dr. Galecio-Castillo is a neurologist and physician-scientist whose research focuses on cerebrovascular disease. As Scientific Lead of the CVNI Lab, she plays an active role in shaping the lab’s scientific direction, leads research projects, and mentors a multidisciplinary research team. Her work combines clinical neurology and quantitative methods, with particular expertise in biostatistics and causal inference. She applies these approaches to investigate clinically meaningful questions of treatment effects, prognosis, and disease mechanisms. Her methodological interests also include predictive modeling, machine learning, and clinical trial design. A central theme of her research is understanding how cerebral hemodynamics, autoregulation, and collateral circulation influence tissue injury, treatment response, and outcomes after stroke. Dr. Galecio-Castillo completed her neurology residency in Peru before pursuing a research career in the United States. Under the mentorship of Dr. Ortega-Gutierrez, she contributes to grant-funded research and a growing body of scholarly work aimed at advancing stroke care.

Clinical Trial Unit

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Palak Tiwari, BS

Title/Position
Global Studies Coordinator
Palak Tiwari is a Global Studies Coordinator in the Cerebrovascular & Neurointerventional Lab, where she drives the execution of complex, multi-site cerebrovascular clinical trials. She serves as a central link between investigators, research teams, and collaborating partners, coordinating trial operations while maintaining regulatory, data-quality, and protocol standards across sites. Palak earned a Bachelor of Science in Cellular and Molecular Biology from Missouri State University and is completing her graduate training in Medical Sciences with a concentration in Medical Physiology. With a professional background in trauma and acute care surgery research, she brings expertise across the full research cycle, bridging the scientific and operational demands of clinical research. At the CVNI Lab, her work reflects a broader commitment to translating rigorous research into meaningful advances in cerebrovascular care.
JuniorVillalobos

Junior Villalobos, BSN, MBA

Title/Position
Lead Clinical Data Manager
Junior Chywai Villalobos Tsui is a Costa Rican nurse who graduated with honors from the Universidad de Costa Rica and holds an MBA focused on artificial intelligence in business. As Lead Clinical Data Manager at the Cerebrovascular & Neurointerventional Laboratory, he supports two concurrent multinational stroke trials (DONE SYMPLE & DIRECT), leading end-to-end data management and managing imaging data from DICOM intake and organization through reconciliation against the clinical database. His background includes managing data for oncology trials and writing software requirements specifications for cardiovascular imaging applications. Those skills drive a second line of work in the lab: designing and building automation and intelligent data collection tools for the team's day-to-day operations, while advancing data quality, efficiency, and scalability across both trials.

Clinical & Research Sciences Unit

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Anderson Brito Alvarado, MD

Title/Position
Research Fellow
Dr. Brito Alvarado earned his medical degree from Universidad Nacional Pedro Henríquez Ureña (UNPHU) in the Dominican Republic. He has a deep passion for clinical research and is dedicated to advancing patient care through innovative approaches in neurosurgery. Aspiring to become a neurological surgeon, his focus is on improving outcomes for patients with critical neurological conditions. Prior to joining the Cerebrovascular and Neurointerventional (CVNI) lab, Dr. Brito Alvarado served as a research fellow at the Dominican Gamma Knife Center, where he co-authored several publications on Gamma Knife radiosurgery.
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Ranferi Herrera Calderon, MD

Title/Position
Research Fellow
Dr. Ranferi Herrera earned his medical degree from Universidad Anáhuac México, where he also completed academic training in humanism and ethics, bioethics, and leadership. He completed a research year at the Cerebrovascular Disease Clinic of the National Institute of Neurology and Neurosurgery in Mexico City and gained U.S. clinical experience in neurology and stroke. His research experience includes clinical trials and projects across diverse areas of cerebrovascular disease. He has contributed to peer-reviewed publications, scientific presentations, and continuing medical education initiatives in neurology and stroke care. He aims to become an academic endovascular neurologist focused on advancing cerebrovascular care and improving access to effective stroke treatments.
Peichum

Peichun Hsu, MD

Title/Position
PhD Candidate
Dr. Peichun Hsu is a Taiwan board-certified neurologist who earned his Doctor of Medicine degree in 2019. Building on his clinical background, he is currently pursuing a PhD in Epidemiology at the University of Iowa. Dr. Hsu’s research focuses on cerebrovascular health outcomes, with a particular interest in acute ischemic stroke outcome analysis, endovascular thrombectomy (EVT) procedures, and post-procedural patient trajectories. By combining his clinical expertise in neurology with advanced statistical methodologies—including longitudinal modeling and causal mediation analysis—he is dedicated to driving innovations in neurointerventional research and improving treatment strategies for patients with cerebrovascular diseases.
Milad

Milad Arzani, MS

Title/Position
PhD Candidate
Milad is an Iranian researcher who earned his master’s degree in Mechanical Engineering from the University of Tehran in 2021. He is currently a 4th year PhD candidate in Biomedical Engineering at the University of Iowa, where his doctoral research has evolved from the biofabrication and tissue engineering of silk-based biomaterials to the study of cerebrovascular disease. Drawing on his background in mechanics and biomaterials, he now combines mechanical testing with imaging-based methods to characterize the microstructure, biomechanical properties, and radiological appearance of blood clots associated with acute ischemic stroke. In collaboration with Dr. Santiago Ortega-Gutiérrez and Professor Suresh M. L. Raghavan, Milad investigates how these clot characteristics can inform the development and evaluation of thrombectomy devices and thrombolytic drugs, with the broader goal of advancing clinically driven technologies and treatment strategies that improve outcomes for patients with stroke.
Leo

Leonardo Cruz-Criollo, MD

Title/Position
Research Fellow
Dr. Leonardo Cruz-Criollo is a Peruvian neurologist who completed his residency at the renowned Instituto Nacional de Ciencias Neurológicas through the Universidad Nacional Mayor de San Marcos (UNMSM). During his residency, he developed a deep interest in vascular neurology, endovascular neurology, and neurocritical care. As part of his residency training, he enhanced his expertise through observerships in Canada and Mexico, focusing on vascular and endovascular neurology. Driven by his passion for advancing medical knowledge and innovative treatments, Dr. Cruz-Criollo came to the United States to collaborate on research in cerebrovascular diseases, neurocritical care and neurointervention. He is committed to driving innovations that transform clinical practices and improve patient outcomes.

Undergraduate Students

Huynh Jenny

Jenny Huynh

Title/Position
Senior Student
Jenny Huynh is an undergraduate student at the University of Iowa studying Biology. Her interest in neurology research stems from her desire to learn more about the human brain and her past experiences volunteering with the hospital's neuroscience unit. She plans on going to medical school and hopes to make meaningful differences in the lives of patients.
Adam

Adam Deters

Title/Position
Student
Adam Deters is an undergraduate student studying Human Physiology. His passion for the health sciences drives his curiosity to be involved with neurology research while contributing to important work improving patient outcomes. Adam hopes to become a physician and work to provide high-quality care to patient populations.
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Afton Ronna

Title/Position
Student
Afton Ronna is an undergraduate student at the University of Iowa studying Human Physiology and Spanish. Her interest in neurology research is driven by her desire to explore all different aspects of healthcare in order to improve patient care and continue fostering connections across UI Healthcare. Aspiring to attend medical school, Afton believes that experiencing the full spectrum of medicine is vital to her journey to becoming a passionate, well-rounded provider.
annabelle

Annabelle Ruth

Title/Position
Student
Annabelle Ruth is an undergraduate student at the University of Iowa studying Interdepartmental Studies in Health Sciences. Her interest in neurological research comes from her curiosity about how the brain works and desire to use that to help improve future patients' lives. She plans on going to medical school and hopes to contribute to advancements in patient care and treatment.