400+

peer-reviewed publications

2

active NIH R01 grants

3

investigator-initiated trials led

10+

countries enrolling across 40+ trial sites

Mission

The Cerebrovascular and Neurointerventional Research Laboratory is dedicated to pioneering advancements in the field of Neurointerventional surgery. Our research team is deeply committed to enhancing clinical practices and outcomes for patients suffering from a spectrum of cerebrovascular disorders, including stroke, aneurysmal subarachnoid hemorrhage, unruptured aneurysms, carotid artery disease, cerebral venous sinus thrombosis (CVST), and other related conditions. Through our focused clinical research, we strive to forge new frontiers in endovascular treatments and patient care.

Santiago Ortega-Gutierez

Santiago Ortega-Gutierrez

Lab Director

Professor of Neurology, Neurosurgery and Radiology
President of the Society of Vascular and Interventional Neurology

Vice Chair, Mechanical Thrombectomy 2020+ Initiative

Director of Neurointerventional Surgery in Neurology

Director, Neuroendovascular Surgical Neuroradiology Fellowship
Department of Neurology, Neurosurgery and Radiology

MAP-STROKE

Speaking at ESOC 2025, Dr. Ortega-Gutierrez explains how MAP-STROKE uses a Bayesian algorithm and geo-mapping to route stroke patients where they are most likely to recover - cutting thrombectomy delays by over 90 minutes, and by more than two hours in rural areas.

Mission Thrombectomy

The Society of Vascular and Interventional Neurology (SVIN) is working to reduce access gaps in stroke care worldwide. This video features leading experts in the field, including our lab director, Dr. Santiago Ortega-Gutierrez, current SVIN President.

Explore the lab

Publications

Over 400 peer-reviewed papers, grouped by year, each linked to its DOI.

International Program

Visiting scholars, fellows, and partner sites training and publishing with the lab.

MAP-STROKE

An NIH-funded in-silico trial of a prehospital routing algorithm for stroke triage.

Meet the Team

Faculty, fellows, research staff, and alumni of the lab, with their roles and research focus.

Grants & Research

NIH, PCORI, and industry-funded international trials including: DONE SYMPLE and DIRECT.

Conference Presentations

Abstracts, platform talks, and posters from ESOC, SVIN, AAN, and ISC.

News and media

Card Map Stroke

MAP-STROKE in Medscape

Coverage of our in-silico trial of prehospital stroke routing, presented at ESOC 2025.

Card DONESYMPLE

DONE SYMPLE with Methinks AI

An international study evaluating AI for stroke diagnosis on non-contrast CT.

Card DIRECT

$705.6M in research funding

The University of Iowa reached a record year, and our PCORI-funded DIRECT trial is part of it.